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Literature summary for 1.6.1.2 extracted from

  • Persson, B.; Rydström, J.
    Evidence for a role of a vicinal dithiol in catalysis and proton pumping in mitochondrial nicotinamide nucleotide transhydrogenase (1987), Biochem. Biophys. Res. Commun., 142, 573-578.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glutathione inhibition of forward and reverse reaction in the presence of NADPH, no inhibition of forward reaction in the presence of NADH, 40% inhibition of reverse reaction, little or no inhibition in the absence of substrates Bos taurus
glutathione disulfide strong, time dependent inhibition of thio-NADP+ reduction by NADH and acetylpyridine adenine dinucleotide reduction by NADPH, 50% inhibition after 40 min incubation in 26.7 mM glutathione disulfide, presence of NADPH accelerates inhibition 20fold Bos taurus
Phenylarsine oxide 0.448 mM, 50% inhibition of acetylpyridine adenine dinucleotide reduction by NADPH after 1 min, 97% inhibition after 60 min, addition of glutathione restores about 50% of activity Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Bos taurus 31966
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+
-
Bos taurus NAD+ + NADPH
-
?
NADH + thio-NADP+
-
Bos taurus NAD+ + thio-NADPH
-
r
NADPH + oxidized 3-acetylpyridine adenine dinucleotide
-
Bos taurus NADP+ + reduced 3-acetylpyridine adenine dinucleotide
-
r

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Bos taurus
NADH
-
Bos taurus
NADP+
-
Bos taurus
NADPH
-
Bos taurus