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Literature summary for 1.6.1.2 extracted from

  • Jackson, J.B.; White, S.A.; Quirk, P.G.; Venning, J.D.
    The alternating site, binding change mechanism for proton translocation by Transhydrogenase (2002), Biochemistry, 41, 4173-4185.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
dI2dIII1 complex and dI domain Rhodospirillum rubrum
dIII domain Homo sapiens
dIII domain Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Dicyclohexylcarbodiimide complete inhibition if 0.5 mol are bound to 1 mol of enzyme Bos taurus
fluorosulfonyl-para-benzyladenosine complete inhibition if 0.5 mol are bound to 1 mol of enzyme Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-
membrane
-
Homo sapiens 16020
-
membrane
-
Bos taurus 16020
-
membrane
-
Entamoeba histolytica 16020
-
membrane
-
Rhodospirillum rubrum 16020
-
mitosome
-
Entamoeba histolytica 32047
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Escherichia coli links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione NAD+ + NADPH
-
r
NADH + NADP+ Homo sapiens links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione NAD+ + NADPH
-
r
NADH + NADP+ Bos taurus links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione NAD+ + NADPH
-
r
NADH + NADP+ Entamoeba histolytica links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione NAD+ + NADPH
-
r
NADH + NADP+ Rhodospirillum rubrum links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione NAD+ + NADPH
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Entamoeba histolytica
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
-
-
Rhodospirillum rubrum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+
-
Escherichia coli NAD+ + NADPH
-
r
NADH + NADP+
-
Homo sapiens NAD+ + NADPH
-
r
NADH + NADP+
-
Bos taurus NAD+ + NADPH
-
r
NADH + NADP+
-
Entamoeba histolytica NAD+ + NADPH
-
r
NADH + NADP+
-
Rhodospirillum rubrum NAD+ + NADPH
-
r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione Escherichia coli NAD+ + NADPH
-
r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione Homo sapiens NAD+ + NADPH
-
r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione Bos taurus NAD+ + NADPH
-
r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione Entamoeba histolytica NAD+ + NADPH
-
r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, hydride ion equivalent is transferred from the A side of NC4 of NADH to the B side of NC4 of NADP+, provides NADPH for metabolic biosynthesis and reduction of glutathione Rhodospirillum rubrum NAD+ + NADPH
-
r

Subunits

Subunits Comment Organism
dimer monomer is split into PntA and PntB chain, enzyme displays an overall dimeric structure Escherichia coli
dimer monomer is split into PntAA, PntAB, and PntB chain, enzyme displays an overall dimeric structure, dI dimers are formed in solutions of isolated dI domains Rhodospirillum rubrum
monomer solution of isolated dIII domains Rhodospirillum rubrum
trimer trimers of dI2dIII1 are formes in mixed solutions containing dI and dIII domains Rhodospirillum rubrum

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Escherichia coli
NAD(P)+
-
Homo sapiens
NAD(P)+
-
Bos taurus
NAD(P)+
-
Entamoeba histolytica
NAD(P)+
-
Rhodospirillum rubrum
NAD(P)H
-
Escherichia coli
NAD(P)H
-
Homo sapiens
NAD(P)H
-
Bos taurus
NAD(P)H
-
Entamoeba histolytica
NAD(P)H
-
Rhodospirillum rubrum