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Literature summary for 1.6.1.2 extracted from

  • Arkblad, E.L.; Egorov, M.; Shakhparonov, M.; Romanova, L.; Polzikov, M.; Rydstrom, J.
    Expression of proton-pumping nicotinamide nucleotide transhydrogenase in mouse, human brain and C. elegans (2002), Comp. Biochem. Physiol. B, 133, 13-21.
    View publication on PubMed
Search for more literature for 1.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information forward reaction stimulated by proton gradient from respiratory chain Mus musculus
additional information forward reaction stimulated by proton gradient from respiratory chain Homo sapiens
additional information forward reaction stimulated by proton gradient from respiratory chain Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane
-
 Mus musculus 5743
-
mitochondrial inner membrane
-
 Homo sapiens 5743
-
mitochondrial inner membrane
-
 Caenorhabditis elegans 5743
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + NADP+ Mus musculus links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, important for the oxidative stress defense NAD+ + NADPH
-
 r
NADH + NADP+ Homo sapiens links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, important for the oxidative stress defense NAD+ + NADPH
-
 r
NADH + NADP+ Caenorhabditis elegans links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, important for the oxidative stress defense NAD+ + NADPH
-
 r

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Mus musculus
-
bladder
-
 Mus musculus
-
brain
-
 Mus musculus
-
brain
-
 Homo sapiens
-
caudate putamen
-
 Homo sapiens
-
cerebellum
-
 Homo sapiens
-
cerebral cortex
-
 Homo sapiens
-
frontal lobe
-
 Homo sapiens
-
gut very strong expression Caenorhabditis elegans
-
heart highest expression level Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
medulla oblongata
-
 Homo sapiens
-
additional information ubiquitous enzyme present in virtually all animal tissues Mus musculus
-
occipital pole
-
 Homo sapiens
-
ovary
-
 Mus musculus
-
pancreas
-
 Mus musculus
-
spinal cord
-
 Homo sapiens
-
temporal lobe
-
 Homo sapiens
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + NADP+
-
 Mus musculus NAD+ + NADPH
-
 r
NADH + NADP+
-
 Homo sapiens NAD+ + NADPH
-
 r
NADH + NADP+
-
 Caenorhabditis elegans NAD+ + NADPH
-
 r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, important for the oxidative stress defense Mus musculus NAD+ + NADPH
-
 r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, important for the oxidative stress defense Homo sapiens NAD+ + NADPH
-
 r
NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the translocation of protons across membrane, important for the oxidative stress defense Caenorhabditis elegans NAD+ + NADPH
-
 r

Synonyms

Synonyms Comment Organism
proton-translocating nicotinamide nucleotide transhydrogenase
-
 Mus musculus
proton-translocating nicotinamide nucleotide transhydrogenase
-
 Homo sapiens
proton-translocating nicotinamide nucleotide transhydrogenase
-
 Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
 Mus musculus
NAD(P)+
-
 Homo sapiens
NAD(P)+
-
 Caenorhabditis elegans
NAD(P)H
-
 Mus musculus
NAD(P)H
-
 Homo sapiens
NAD(P)H
-
 Caenorhabditis elegans