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Literature summary for 1.6.2.2 extracted from

  • Siddique, Y.; Ara, G.; Gupta, J.; Beg, T.; Afzal, M.
    Estimation of cytochrome b5 reductase activity in red blood cells of Rattus norvegicus after the treatment of trichloroacetic acid (2009), Pharmacologyonline, 3, 986-990.
No PubMed abstract available
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + methemoglobin Rattus norvegicus
-
 NAD+ + hemoglobin
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome b5 + NADH
-
 Rattus norvegicus 2 ferrocytochrome b5 + NAD+ + H+
-
 ?
NADH + methemoglobin
-
 Rattus norvegicus NAD+ + hemoglobin
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome b5 reductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus
NADH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus a significant increase in the activity of cytochrome b5 reductase is observed after trichloroaceticacid treatment at 0.2% (w/v) (about 12 mM) concentration in drinking water ad libitum for 60 days as compared to control groups up

General Information

General Information Comment Organism
physiological function cytochrome b5 reductase is responsible for the reduction of methemoglobin back to hemoglobin Rattus norvegicus