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Literature summary for 1.6.2.4 extracted from

  • McGuire, J.J.; Anderson, D.J.; McDonald, B.J.; Narayanasami, R.; Bennett, B.M.
    Inhibition of NADPH-Cytochrome P450 Reductase and Glyceryl Trinitrate Biotransformation by Diphenyleneiodonium Sulfate (1998), Biochem. Pharmacol., 56, 881-893.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
diphenylene iodonium sulfate time-dependent and concentration-dependent inhibition of cDNA-expressed liver enzyme as well as aortic and hepatic microsomal enzyme activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001 0.003 NADPH
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome 0.03 to 0.1% of aortic microsomal protein Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Sprague-Dawley strain
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley strain
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0104
-
aortic microsomal preparation Rattus norvegicus
16.5
-
cDNA-expressed liver enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADPH additional electron acceptor: cytochrome P450 Rattus norvegicus 2 ferrocytochrome c + NADP+ + H+
-
?
2 ferricytochrome c + NADPH additional electron acceptor: cytochrome P450 Rattus norvegicus Sprague-Dawley 2 ferrocytochrome c + NADP+ + H+
-
?
additional information denitration of glyceryl trinitrate Rattus norvegicus ?
-
?
additional information denitration of glyceryl trinitrate Rattus norvegicus Sprague-Dawley ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
21.3
-
cytochrome c aortic microsomal enzyme Rattus norvegicus
21.9
-
cytochrome c purified enzyme Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus
FMN
-
Rattus norvegicus
NADPH
-
Rattus norvegicus