Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diphenylene iodonium sulfate | time-dependent and concentration-dependent inhibition of cDNA-expressed liver enzyme as well as aortic and hepatic microsomal enzyme activity | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | 0.003 | NADPH | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | 0.03 to 0.1% of aortic microsomal protein | Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley strain | - |
Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0104 | - |
aortic microsomal preparation | Rattus norvegicus |
16.5 | - |
cDNA-expressed liver enzyme | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ferricytochrome c + NADPH | additional electron acceptor: cytochrome P450 | Rattus norvegicus | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
2 ferricytochrome c + NADPH | additional electron acceptor: cytochrome P450 | Rattus norvegicus Sprague-Dawley | 2 ferrocytochrome c + NADP+ + H+ | - |
? | |
additional information | denitration of glyceryl trinitrate | Rattus norvegicus | ? | - |
? | |
additional information | denitration of glyceryl trinitrate | Rattus norvegicus Sprague-Dawley | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21.3 | - |
cytochrome c | aortic microsomal enzyme | Rattus norvegicus | |
21.9 | - |
cytochrome c | purified enzyme | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Rattus norvegicus | |
FMN | - |
Rattus norvegicus | |
NADPH | - |
Rattus norvegicus |