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Literature summary for 1.6.2.4 extracted from

  • Yao, H.T.; Chang, Y.W.; Lan, S.J.; Yeh, T.K.
    The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes (2008), Food Chem. Toxicol., 46, 645-653.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Tannic acid
-
Homo sapiens
Tannic acid
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-
microsome
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome P450 + NADPH
-
Homo sapiens 2 ferrocytochrome P450 + NADP+ + H+
-
?

Synonyms

Synonyms Comment Organism
NADPH-CYP reductase
-
Homo sapiens
NADPH-CYP reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0118
-
-
Rattus norvegicus Tannic acid
0.0174
-
-
Homo sapiens Tannic acid