Literature summary for 1.6.2.4 extracted from

DAgostino, J.; Ding, X.; Zhang, P.; Jia, K.; Fang, C.; Zhu, Y.; Spink, D.C.; Zhang, Q.Y.
Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes (2012), J. Biol. Chem., 287, 17777-17788.

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Protein Variants

Protein Variants	Comment	Organism
additional information	comparison of enzyme gene expression in enterocytes isolated from the small intestine of intestinal epithelium-specific Por knock-out mice, i.e. IE-Cpr-null mice, and that observed in wild-type littermates, overview. Cholesterol biosynthetic activity is greatly reduced in the enterocytes of the IE-Cpr-null mice, as evidenced by the accumulation of the lanosterol metabolite, 24-dihydrolanosterol. Levels of the cholesterol precursor farnesyl diphosphate and its derivative geranylgeranyl pyrophosphate are also increased in the enterocytes of the IE-Cpr-null mice. Expression of STAT1 (signal transducer and activator of transcription 1), a downstream target of geranylgeranyl pyrophosphate signaling, is enhanced	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Mus musculus	-	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
enterocyte	-	Mus musculus	-
small intestine	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cytochrome P450 reductase	-	Mus musculus
NADPH-cytochrome P450 reductase	-	Mus musculus
POR	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	NADPH-cytochrome P450 reductase is essential for the functioning of microsomal cytochrome P450 monooxygenases and heme oxygenases. Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine in expression of major histocompatibility complex class II genes	Mus musculus

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Release 2023.1 (January 2023)