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Literature summary for 1.6.3.1 extracted from

  • De Deken, X.; Wang, D.; Dumont, J.E.; Miot, F.
    Characterization of ThOX proteins as components of the thyroid H2O2-generating system (2002), Exp. Cell Res., 273, 187-196.
    View publication on PubMed
Search for more literature for 1.6.3.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin enhances expression of protein Canis lupus familiaris

Cloned(Commentary)

Cloned (Comment) Organism
Cos-7, CHO, Hek293, NIH3T3, HeLa and PLB-XCGD cells transfected with ThOX2 DNA, protein is expressed but is exclusively found in cytoplasm and shows no activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diphenylene iodonium
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
apical plasma membrane
-
 Rattus norvegicus 16324
-
apical plasma membrane
-
 Canis lupus familiaris 16324
-
apical plasma membrane minor part of protein is expressed at cell surface, not found at surface of transfected CHO and PLB-XCGD cells Homo sapiens 16324
-
cytoplasm major part of protein Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ regulates enzyme activity Homo sapiens
Ca2+ regulates enzyme activity Rattus norvegicus
Ca2+ regulates enzyme activity Canis lupus familiaris

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
160000
-
 SDS-PAGE, deglycosylated form Homo sapiens
180000
-
 SDS-PAGE, protein from transfected cells Homo sapiens
190000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD(P)H + H+ + O2 Homo sapiens production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Rattus norvegicus production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 Canis lupus familiaris production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis NAD(P)+ + H2O2
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
 cell line PC C-13
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein 5 N-glycosylation sites Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
thyroid gland
-
 Rattus norvegicus
-
thyroid gland follicular cells Homo sapiens
-
thyroid gland follicular cells Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD(P)H + H+ + O2
-
 Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Rattus norvegicus NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2
-
 Canis lupus familiaris NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Homo sapiens NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Rattus norvegicus NAD(P)+ + H2O2
-
 ?
NAD(P)H + H+ + O2 production of hydrogen peroxide in thyroid gland that is required for thyroid hormone synthesis Canis lupus familiaris NAD(P)+ + H2O2
-
 ?