Literature summary for 1.6.3.1 extracted from

Liu, R.; Garvin, J.L.; Ren, Y.; Pagano, P.J.; Carretero, O.A.
Depolarization of the macula densa induces superoxide production via NAD(P)H oxidase (2007), Am. J. Physiol. Renal Physiol., 292, F1867-F1872.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	when luminal NaCl in kidney is switched from 10 to 80 mM, a situation of initiating maximum tubuloglomerular feedback response, superoxide anion production significantly increases. In the presence of apocynin, superoxide anion production is inhibited by 80%	Oryctolagus cuniculus

Application

Application	Comment	Organism
medicine	in macula densa, increasing luminal NaCl induces superoxide anion production during tubuloglomerular feedback. Superoxide anion generated by the macula densa is primarily derived from NAD(P)H oxidase and is induced by depolarization	Oryctolagus cuniculus

Inhibitors

Inhibitors	Comment	Organism	Structure
apocynin	when luminal NaCl in kidney is switched from 10 to 80 mM, a situation of initiating maximum tubuloglomerular feedback response, superoxide anion production significantly increases. In the presence of apocynin, superoxide anion production is inhibited by 80%	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	loop of Henle and macula densa	Oryctolagus cuniculus	-

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Release 2023.1 (January 2023)