Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phorbol 12-myristate 13-acetate | upon treatment, plasma membranes from stimulated cells show an increased amount of regulatory protein Rac1, but other components of the NAD(P)H oxidase complex do not change before and after the stimulation. When the constitutively active form of Rac, Q61L or GTP-bound Rac1 is added exogenously to the membrane, superoxied anion producing activity is enhanced up to 1.5-fold above the basal level,but GDP-loaded Rac1 does not affect superoxide generating kinetics | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a fusion protein NOXA1N-RacQ61L between truncated subunit NOXA1 residues1-211 and constitutively active Rac1 mutant Q61L exhibits 6-fold increase of the basal Nox1 activity, but C-terminal truncated NOXO1 residues 1-292 show little effect on the activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | active subunit Nox1 endogenously co-localizes with its regulatory components p22phox, NOXO1, NOXA1 and Rac1 | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |