Literature summary for 1.6.3.1 extracted from

Schlueter, T.; Steinbach, A.C.; Steffen, A.; Rettig, R.; Grisk, O.
Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition (2008), Cardiovasc. Res., 80, 271-279.

Search for more literature for 1.6.3.1

Protein Variants

Protein Variants	Comment	Organism
additional information	aortic rings from mice deificient in subunit p47phox are more sensitive to apocynin-induced dilation than wild-type aortic rings	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
apocynin	aortic rings from mice deificient in subunit p47phox are more sensitive to apocynin-induced dilation than wild-type aortic rings. Rho kinase inhibition reduces or prevents the inhibitory effect of apocynin on agonist-induced vasoconstriction and apocynin inhibits the phosphorylation of Rho kinase substrates	Mus musculus
apocynin	apocynin does not reduce arterial pressure acutely in spontaneously hpertensive rats when given orally over 1-week intervals or when given i.v. Apocynin potently inhibits granulocyte NADPH oxidase but not vascular NADPH-oxidase dependent oxygen radical formation unless exogenous peroxidase is added to vascular preparations. Apocynin dilates rat intrarenal and coronary arteries independently of pharmacological interventions that reduce vascular superoxide radical abundance and actions	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	spontaneously hypertensive rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	aortic rings	Mus musculus	-

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Release 2023.1 (January 2023)