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Literature summary for 1.6.3.1 extracted from

  • Mittal, M.; Roth, M.; Koenig, P.; Hofmann, S.; Dony, E.; Goyal, P.; Selbitz, A.C.; Schermuly, R.T.; Ghofrani, H.A.; Kwapiszewska, G.; Kummer, W.; Klepetko, W.; Hoda, M.A.; Fink, L.; Haenze, J.; Seeger, W.; Grimminger, F.; Schmidt, H.H.; Weissmann, N.
    Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature (2007), Circ. Res., 101, 258-267.
    View publication on PubMed

Application

Application Comment Organism
medicine hypoxic conditions lead to upregulation exclusively of NOX4 mRNA in lung, concomitant with increased levels in microdissected pulmonary arterial vessels. NOX4 mRNA and protein are localized predominantly in the media of small pulmonary arteries, with increased labeling intensities after chronic exposure to hypoxia. In isolated pulmonary arterial smooth muscle cells, NOX4 is localized primarily to the perinuclear space Mus musculus
medicine in lungs from patients with idiopathic pulmonary arterial hypertension, expression levels of NOX4, which is localized in the vessel media, are 2.5-fold upregulated Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients with idiopathic pulmonary arterial hypertension
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
lung
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Homo sapiens
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lung presence of subunits NOX1, NOXA1, NOXO1, p22phox, p47phox, p40phox, p67phox, NOX2, and NOX4. Hypoxic conditions lead to upregulation exclusively of NOX4 mRNA, concomitant with increased levels in microdissected pulmonary arterial vessels. NOX4 mRNA and protein are localized predominantly in the media of small pulmonary arteries, with increased labeling intensities after chronic exposure to hypoxia. In isolated pulmonary arterial smooth muscle cells, NOX4 is localized primarily to the perinuclear space Mus musculus
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