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Literature summary for 1.6.3.1 extracted from

  • Coyoy, A.; Valencia, A.; Guemez-Gamboa, A.; Moran, J.
    Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons (2008), Free Radic. Biol. Med., 45, 1056-1064.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-(2-aminoethyl)benzenesulfonyl fluoride significantly reduces reactive oxygen species production, NADPH oxidase activity, and all the apoptotic events, and cell death induced by both 5 mM KCl and staurosporin Rattus norvegicus
diphenylene iodonium significantly reduces reactive oxygen species production, NADPH oxidase activity, and all the apoptotic events, and cell death induced by both 5 mM KCl and staurosporin Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
neuron in primary cultures of cerebellar granule neuron, expression of the components of NADPH oxidase proteins, p40phox, p47phox and p67phox,and p22phox, as well as three homologues of the catalytic subunit, NOX1, 2, and 4 Rattus norvegicus
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