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Literature summary for 1.6.3.1 extracted from

  • Nakashima, T.; Iwashita, T.; Fujita, T.; Sato, E.; Niwano, Y.; Kohno, M.; Kuwahara, S.; Harada, N.; Takeshita, S.; Oda, T.
    A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac (2008), J. Biochem., 143, 107-115.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(5'Z)-5'-[(4-heptyl-5-methyl-1H-pyrrol-2-yl)methylidene]-4'-methoxy-1H,5'H-2,2'-bipyrrole i.e. PG-L-1, prodigosin analogue, a red pigment isolated from marine bacterial strain. Significant inhibition of superoxide anion production by phorbol 12-myristate 13-acetate stimulated RAW 264.7 cells. (5'Z)-5'-[(4-heptyl-5-methyl-1H-pyrrol-2-yl)methylidene]-4'-methoxy-1H,5'H-2,2'-bipyrrole strongly inhibits the association of subunits p47phox and Rac in the plasma membrane Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
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Mus musculus
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