Literature summary for 1.6.3.1 extracted from

Jang, H.J.; Hwang, S.; Cho, K.Y.; Kim, d.o..K.; Chay, K.O.; Kim, J.K.
Taxol induces oxidative neuronal cell death by enhancing the activity of NADPH oxidase in mouse cortical cultures (2008), Neurosci. Lett., 443, 17-22.

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Inhibitors

Inhibitors	Comment	Organism	Structure
taxol	induces concentration-dependent neuronal death with apoptotoic features. Neuronal death is significantly attenuated by anti-apoptotic rugs and by antioxidants such as trolox, ascorbic acid, and tempol. Exposure to taxol increases the expression of NAD(P)H oxidase subunits p45phox and gp91phox and induces translocation of p47phox protein to the membrane in cortical cultures	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	exposure to taxol induces translocation of p47phox protein to the membrane in cortical cultures	Mus musculus	16020	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebral cortex	cortical culture	Mus musculus	-

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Release 2023.1 (January 2023)