Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
podocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + H+ + O2 | - |
Mus musculus | NAD+ + H2O2 | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
heme | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | 2 mM metformin induces suppression of NAD(P)H oxidase activity by 45% in high glucose (30 mM) and by 60% in normal glucose concentrations (5.6 mM) | down |
Mus musculus | high glucose concentration (30 mM) increases NAD(P)H oxidase activity by about 27% | up |
General Information | Comment | Organism |
---|---|---|
physiological function | NAD(P)H oxidase is the main source of reactive oxygen species in diabetic podocytes and their production contributes to the development of diabetic nephropathy | Mus musculus |