Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apocynin | selective NAD(P)H oxidase inhibitor | Homo sapiens | |
apocynin | selective NAD(P)H oxidase inhibitor | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
aortic endothelial cell | - |
Mus musculus | - |
HUVEC cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + H+ + O2 | - |
Mus musculus | NAD+ + H2O2 | - |
? | |
NADH + H+ + O2 | - |
Homo sapiens | NAD+ + H2O2 | - |
? | |
NADPH + H+ + O2 | - |
Mus musculus | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | - |
Homo sapiens | NADP+ + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gp91phox | subunit | Mus musculus |
gp91phox | subunit | Homo sapiens |
NOX1 | subunit | Mus musculus |
NOX1 | subunit | Homo sapiens |
Nox2 | subunit | Mus musculus |
Nox2 | subunit | Homo sapiens |
NOX3 | subunit | Mus musculus |
NOX3 | subunit | Homo sapiens |
Nox4 | subunit | Mus musculus |
Nox4 | subunit | Homo sapiens |
p47phox | subunit | Mus musculus |
p47phox | subunit | Homo sapiens |
p67phox | subunit | Mus musculus |
p67phox | subunit | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Mus musculus | |
FAD | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced suppression of NAD(P)H oxidase subunit expression is AMP-activated protein kinase alpha2-dependent | down |
Homo sapiens | 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced suppression of NAD(P)H oxidase subunit expression is AMP-activated protein kinase alpha2-dependent | down |
Mus musculus | loss of AMP-activated protein kinase activity increases NAD(P)H oxidase subunit expression (gp91phox, p47phox, p67phox, NOX1 and -4) and NAD(P)H oxidase-mediated superoxide production | up |
Homo sapiens | loss of AMP-activated protein kinase activity increases NAD(P)H oxidase subunit expression (gp91phox, p47phox, p67phox, NOX1 and -4) and NAD(P)H oxidase-mediated superoxide production | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of NAD(P)H oxidase abolishes endothelial dysfunction in AMP-activated protein kinase alpha2-deficient mice | Mus musculus |