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Literature summary for 1.6.3.1 extracted from

  • Wang, S.; Zhang, M.; Liang, B.; Xu, J.; Xie, Z.; Liu, C.; Viollet, B.; Yan, D.; Zou, M.H.
    AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes (2010), Circ. Res., 106, 1117-1128.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
apocynin selective NAD(P)H oxidase inhibitor Homo sapiens
apocynin selective NAD(P)H oxidase inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-
membrane
-
Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Mus musculus
-
aortic endothelial cell
-
Mus musculus
-
HUVEC cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + O2
-
Mus musculus NAD+ + H2O2
-
?
NADH + H+ + O2
-
Homo sapiens NAD+ + H2O2
-
?
NADPH + H+ + O2
-
Mus musculus NADP+ + H2O2
-
?
NADPH + H+ + O2
-
Homo sapiens NADP+ + H2O2
-
?

Synonyms

Synonyms Comment Organism
gp91phox subunit Mus musculus
gp91phox subunit Homo sapiens
NOX1 subunit Mus musculus
NOX1 subunit Homo sapiens
Nox2 subunit Mus musculus
Nox2 subunit Homo sapiens
NOX3 subunit Mus musculus
NOX3 subunit Homo sapiens
Nox4 subunit Mus musculus
Nox4 subunit Homo sapiens
p47phox subunit Mus musculus
p47phox subunit Homo sapiens
p67phox subunit Mus musculus
p67phox subunit Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Mus musculus
FAD
-
Homo sapiens

Expression

Organism Comment Expression
Mus musculus 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced suppression of NAD(P)H oxidase subunit expression is AMP-activated protein kinase alpha2-dependent down
Homo sapiens 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside-induced suppression of NAD(P)H oxidase subunit expression is AMP-activated protein kinase alpha2-dependent down
Mus musculus loss of AMP-activated protein kinase activity increases NAD(P)H oxidase subunit expression (gp91phox, p47phox, p67phox, NOX1 and -4) and NAD(P)H oxidase-mediated superoxide production up
Homo sapiens loss of AMP-activated protein kinase activity increases NAD(P)H oxidase subunit expression (gp91phox, p47phox, p67phox, NOX1 and -4) and NAD(P)H oxidase-mediated superoxide production up

General Information

General Information Comment Organism
malfunction inhibition of NAD(P)H oxidase abolishes endothelial dysfunction in AMP-activated protein kinase alpha2-deficient mice Mus musculus