Application | Comment | Organism |
---|---|---|
medicine | NADPH oxidase type 4 is a major source of oxidative stress and an effective therapeutic target in acute stroke | Mus musculus |
medicine | NADPH oxidase type 4 is a major source of oxidative stress and an effective therapeutic target in acute stroke | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | Mus musculus | - |
NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | Homo sapiens | - |
NADP+ + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood vessel | - |
Mus musculus | - |
blood vessel | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
cerebrum | - |
Mus musculus | - |
cerebrum | - |
Homo sapiens | - |
endothelial cell | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
neuron | - |
Mus musculus | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + O2 | - |
Mus musculus | NADP+ + H2O2 | - |
? | |
NADPH + H+ + O2 | - |
Homo sapiens | NADP+ + H2O2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH oxidase type 4 | - |
Mus musculus |
NADPH oxidase type 4 | - |
Homo sapiens |
Nox4 | - |
Mus musculus |
Nox4 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | expression of NOX4 mRNA is significantly higher 12 h and 24 h after transient middle cerebral artery occlusion in the basal ganglia and neocortex of wild type mice than in sham-operated controls | up |
Homo sapiens | NOX4 gene expression is stronger in brain samples from stroke patients compared to healthy controls | up |
General Information | Comment | Organism |
---|---|---|
malfunction | mice deficient in NOX4 of either sex, but not those deficient for NOX1 or NOX2, are largely protected from oxidative stress, blood-brain-barrier leakage, and neuronal apoptosis, after both transient and permanent cerebral ischemia | Mus musculus |