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Literature summary for 1.6.3.1 extracted from

  • Polizio, A.H.; Balestrasse, K.B.; Gornalusse, G.G.; Gorzalczany, S.B.; Santa-Cruz, D.M.; Yannarelli, G.G.; Pena, C.; Tomaro, M.L.
    Losartan exerts renoprotection through NAD(P)H oxidase downregulation in a renovascular model of hypertension (2009), Regul. Pept., 156, 28-33.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + O2
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Rattus norvegicus NADP+ + H2O2
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?

Cofactor

Cofactor Comment Organism Structure
FAD
-
Rattus norvegicus
heme
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus losartan administration significantly reduces oxidative stress generation by decreasing NAD(P)H oxidase expression down
Rattus norvegicus a strong upregulation of NAD(P)H oxidase subunits p22phox and p47phox is observed in the hypertensive kidney of aortic coarcted rats up