Literature summary for 1.6.3.5 extracted from

Xu, J.; Li, G.; Wang, P.; Velazquez, H.; Yao, X.; Li, Y.; Wu, Y.; Peixoto, A.; Crowley, S.; Desir, G.V.
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure (2005), J. Clin. Invest., 115, 1275-1280.

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Application

Application	Comment	Organism
medicine	plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects	Homo sapiens
medicine	renalase infusion in rats causes a decrease in cardiac contractility, heart rate, and blood pressure and prevents a compensatory increase in peripheral vascular tone	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q5VYX0	-	-
Rattus norvegicus	Q5U2W9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	enzyme is secreted into the blood by the kidney	Homo sapiens	-
heart	besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine	Homo sapiens	-
kidney	enzyme is secreted into the blood by the kidney. Gene expression is highest in the kidney	Homo sapiens	-
skeletal muscle	besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine	Homo sapiens	-
small intestine	besides kidney, renalase gene expression is detectable in the heart, skeletal muscle, and the small intestine	Homo sapiens	-

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Release 2023.1 (January 2023)