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Literature summary for 1.6.5.2 extracted from

  • Miseviciene, L.; Anusevicius, Z.; Sarlauskas, J.; Cenas, N.
    Reduction of nitroaromatic compounds by NAD(P)H:quinone oxidoreductase (NQO1): the role of electron-accepting potency and structural parameters in the substrate specificity (2006), Acta Biochim. Pol., 53, 569-576.
    View publication on PubMed
Search for more literature for 1.6.5.2

Inhibitors

Inhibitors Comment Organism Structure
1-hydroxy-2-[2-(nitrooxy)ethyl]-1-oxo-2-(2,4,6-trinitro-3-(nitro[2-(nitrooxy)ethyl]amino)phenyl)diazanium competitive Rattus norvegicus
2,4,6-trinitrotoluene competitive Rattus norvegicus
2-[nitro(2,4,6-trinitrophenyl)amino]ethyl nitrate competitive Rattus norvegicus
4,5,6,7-tetranitro-1,3-dihydro-2H-benzimidazol-2-one competitive Rattus norvegicus
4,5,6-trinitro-1,3-dihydro-2H-benzimidazol-2-one competitive Rattus norvegicus
ethyl 5-aziridin-1-yl-2,4-dinitrobenzoate competitive Rattus norvegicus
hydroxy(oxo)(3,6,8-trinitro-9H-carbazol-1-yl)ammonium competitive Rattus norvegicus
N-methyl-N,2,4,6-tetranitroaniline competitive Rattus norvegicus
N-methyl-N,2,4-trinitroaniline competitive Rattus norvegicus
nitracrine competitive Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-hydroxy-2-[2-(nitrooxy)ethyl]-1-oxo-2-(2,4,6-trinitro-3-(nitro[2-(nitrooxy)ethyl]amino)phenyl)diazanium + NAD(P)H + H+
-
 Rattus norvegicus reduced 1-hydroxy-2-[2-(nitrooxy)ethyl]-1-oxo-2-(2,4,6-trinitro-3-(nitro[2-(nitrooxy)ethyl]amino)phenyl)diazanium + NAD(P)+ ratio kcat to Km value is 52000 per M and s ?
2,4,6-trinitrotoluene + NAD(P)H +
-
 Rattus norvegicus reduced 2,4,6-trinitrotoluene + NAD(P)+ ratio kcat to Km value is 670 per M and s ?
2-[nitro(2,4,6-trinitrophenyl)amino]ethyl nitrate + NAD(P)H +
-
 Rattus norvegicus reduced 2-[nitro(2,4,6-trinitrophenyl)amino]ethyl nitrate + NAD(P)+ ratio kcat to Km value is 570000 per M and s ?
4,5,6,7-tetranitro-1,3-dihydro-2H-benzimidazol-2-one + NAD(P)H +
-
 Rattus norvegicus reduced 4,5,6,7-tetranitro-1,3-dihydro-2H-benzimidazol-2-one + NAD(P)+ ratio kcat to Km value is 5000000 per M and s ?
4,5,6-trinitro-1,3-dihydro-2H-benzimidazol-2-one + NAD(P)H +
-
 Rattus norvegicus reduced 4,5,6-trinitro-1,3-dihydro-2H-benzimidazol-2-one + NAD(P)+ ratio kcat to Km value is 26000 per M and s ?
ethyl 5-aziridin-1-yl-2,4-dinitrobenzoate + NAD(P)H +
-
 Rattus norvegicus reduced ethyl 5-aziridin-1-yl-2,4-dinitrobenzoate + NAD(P)+ ratio kcat to Km value is 20000 per M and s ?
hydroxy(oxo)(3,6,8-trinitro-9H-carbazol-1-yl)ammonium + NAD(P)H +
-
 Rattus norvegicus reduced 2-[nitro(2,4,6-trinitrophenyl)amino]ethyl nitrate + NAD(P)+ ratio kcat to Km value is 500000 per M and s ?
N-methyl-N,2,4,6-tetranitroaniline + NAD(P)H +
-
 Rattus norvegicus reduced N-methyl-N,2,4,6-tetranitroaniline + NAD(P)+ ratio kcat to Km value is 260000 per M and s ?
N-methyl-N,2,4-trinitroaniline + NAD(P)H +
-
 Rattus norvegicus reduced N-methyl-N,2,4-trinitroaniline + NAD(P)+ ratio kcat to Km value is 52000 per M and s ?
nitracrine + NAD(P)H +
-
 Rattus norvegicus reduced nitracrine + NAD(P)+ i.e. N,N-dimethyl-N'-(1-nitro-9,10-dihydroacridin-9-yl)propane-1,3-diamine, ratio kcat to Km value is 1800 per M and s ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0031
-
 hydroxy(oxo)(3,6,8-trinitro-9H-carbazol-1-yl)ammonium pH 7.0, 25°C Rattus norvegicus
0.01
-
 4,5,6,7-tetranitro-1,3-dihydro-2H-benzimidazol-2-one pH 7.0, 25°C Rattus norvegicus
0.017
-
 4,5,6-trinitro-1,3-dihydro-2H-benzimidazol-2-one pH 7.0, 25°C Rattus norvegicus
0.04
-
 nitracrine pH 7.0, 25°C Rattus norvegicus
0.04
-
 N-methyl-N,2,4,6-tetranitroaniline pH 7.0, 25°C Rattus norvegicus
0.05
-
 ethyl 5-aziridin-1-yl-2,4-dinitrobenzoate pH 7.0, 25°C Rattus norvegicus
0.06
-
 N-methyl-N,2,4-trinitroaniline pH 7.0, 25°C Rattus norvegicus
0.08
-
 2,4,6-trinitrotoluene pH 7.0, 25°C Rattus norvegicus
0.095
-
 1-hydroxy-2-[2-(nitrooxy)ethyl]-1-oxo-2-(2,4,6-trinitro-3-(nitro[2-(nitrooxy)ethyl]amino)phenyl)diazanium pH 7.0, 25°C Rattus norvegicus