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Literature summary for 1.6.5.2 extracted from

  • Elbekai, R.H.; Duke, J.; El-Kadi, A.O.
    Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+) (2007), Cancer Lett., 246, 54-62.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ascorbic acid superinduction of the enzyme induction by As3+ Mus musculus

Application

Application Comment Organism
medicine ascorbic acid may potentiate the therapeutic efficacy of As3+ in treatment of acute promyelotic leukemia by enhancing the expression of enzyme together with heme oxygenase-1 and glutathione S-transferase Ya Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Cr6+ decrease of enzyme mRNA level together with heme oxygenase-1 and glutathione S-transferase Ya Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
As3+ induction of enzyme together with heme oxygenase-1 and glutathione S-transferase Ya Mus musculus
Cd2+ induction of enzyme together with heme oxygenase-1 and glutathione S-transferase Ya Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isoform Nqo1
-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa-1c1c7 cell hepatoma cell line Mus musculus
-