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Literature summary for 1.6.5.2 extracted from

  • Moffit, J.S.; Aleksunes, L.M.; Kardas, M.J.; Slitt, A.L.; Klaassen, C.D.; Manautou, J.E.
    Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen (2007), Toxicology, 230, 197-206.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
Clofibrate administration to animals for 5 to 10 days, increase in enzyme protein and activity Mus musculus
Clofibrate administration to animals for 5 to 10 days, increase in enzyme protein and activity Homo sapiens

Application

Application Comment Organism
medicine acetaminophen is bioactivated by cytochrome P450 to the reactive intermediate N-acetyl-p-benzoquinone imine. Enhanced levels of hepatic enzyme may detoxify N-acetyl-p-benzoquinone imine by reducing it back to acetaminophen Homo sapiens
medicine clofibrate-mediated hepatoprotection against acetaminophen does not appear to be dependent upon enhanced expression of enzyme. Conditions of 94% inhobition of enzyme do not increase the susceptibility of hepatocytes from clofibrate treated mice to acetaminophen Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 recombinant isoform NQO1
-
Mus musculus
-
-
-
Mus musculus CD-1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetaminophen + NAD(P)H + H+
-
 Homo sapiens N-acetyl-p-benzoquinone imine + NAD(P)+ enhanced levels of hepatic enzyme may detoxify N-acetyl-p-benzoquinone imine by reducing it back to acetaminophen r