Application | Comment | Organism |
---|---|---|
drug development | design of novel lavendamycin analogues with enhanced, selective, and potent antitumor activity | Homo sapiens |
pharmacology | a series of lavendamycin analogues are tested in docking studies employing an X-ray derived NQO1 active site computational model, structure-based analogue design criteria are valid, resulting in the design of two analogues with high substrate specificity and selective toxicity toward NQO1-rich cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
1H69 crystal structure-based in silico model of NQO1 active site, NQO1 complex with bound FAD and indolequinone | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-N-acetyldemethyllavendamycin n-butyl amide | lavendamycin analogue 12, selective toxic toward NQO1-rich cells | Homo sapiens | |
lavendamycin beta-hydroxyethyl ester | lavendamycin analogue 12, selective toxic toward NQO1-rich cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15559 | - |
- |
Homo sapiens | P15559 | recombinant protein and in human colon adenocarcinoma cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic adenocarcinoma cell | NQO1-deficient BE and NQO1-rich BE-NQ | Homo sapiens | - |
colonic cancer cell | BE human colon adenocarcinoma cells, stably NQO1-transfected BE-NQ cells69 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7-N-(2-furoyl)demethyllavendamycin methyl ester + NADH | poor substrate | Homo sapiens | ? + NAD+ | - |
? | |
7-N-acetyldemethyllavendamycin n-butyl amide + NADH | good substrate | Homo sapiens | ? + NAD+ | - |
? | |
7-N-acetyldemethyllavendamycin sec-butyl amide + NADH | poor substrate | Homo sapiens | ? + NAD+ | - |
? | |
lavendamycin beta-hydroxyethyl ester + NADH | good substrate | Homo sapiens | ? + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H:quinone oxidoreductase 1 | - |
Homo sapiens |
NADPH:quinone oxidoreductase 1 | - |
Homo sapiens |
NQO1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |