Literature summary for 1.6.5.2 extracted from

Korashy, H.M.; Brocks, D.R.; El-Kadi, A.O.
Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection (2007), Cancer Lett., 258, 135-143.

Search for more literature for 1.6.5.2

Activating Compound

Activating Compound	Comment	Organism	Structure
actinomycin D	treatment of the cells with actinomycin D alone for 6 h significantly inhibits the constitutive NQO1 mRNA level by approximately 80%. KTZ- and ITZ-mediated Nqo1 induction is completely inhibited	Mus musculus
itraconazole	induces NQO1 mRNA and enzymatic activity levels in a concentration- and time-dependent manner in wild-type but not aryl hydrocarbon receptor-deficient Hepa-1c1c7 cells. Increases NQO1 de novo RNA synthesis without significantly affecting the levels of existing RNA. 50 micromol shows maximum NQO1 mRNA induction	Mus musculus
ketoconazole	induces NQO1 mRNA and enzymatic activity levels in a concentration- and time-dependent manner in wild-type but not aryl hydrocarbon receptor-deficient Hepa-1c1c7 cells. Increases NQO1 de novo RNA synthesis without significantly affecting the levels of existing RNA. 25 micromol shows maximum NQO1 mRNA induction	Mus musculus
additional information	fluconazole does not induce NQO1	Mus musculus
sulforaphane	at a concentration of 5 micromol significantly induces NQO1 mRNA in both wild-type and C12 cells	Mus musculus

Application

Application	Comment	Organism
drug development	ability of ketoconazole and itraconazole to induce NQO1 gene expression at the transcriptional level through an aryl hydrocarbon receptor-dependent mechanism	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hepa-1c1c7 cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD(P)H + H+ + oxidized 2,6-dichlorophenolindophenol	-	Mus musculus	NAD(P)+ + reduced 2,6-dichlorophenolindophenol	-	?

Synonyms

Synonyms	Comment	Organism
DT-diaphorase	-	Mus musculus
NAD(P)H:quinone oxidoreductase 1	-	Mus musculus
NQO1	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)