Application | Comment | Organism |
---|---|---|
medicine | combination therapy employing a member of the group of non-cytotoxic NQO1 inhibitors together with a 2,6-dichlorophenolindophenol-like molecule may provide therapeutic efficacy against tumors that display high NQO1 enzymatic activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-375 cell | low NQO1 activity. The redox dye 2,6-dichlorophenolindophenol may serve as a prooxidant chemotherapeutic targeting human melanoma cells in vitro and in vivo. DCPIP-apoptogenicity observed in the human melanoma cell lines A375 and G361 is inversely correlated with NAD(P)H:quinone oxidoreductase (NQO1) expression levels. 2,6-Dichlorophenolindophenol apoptogenic potency observed in human A375 and G361 melanoma cells is a function of cellular NQO1 expression levels | Homo sapiens | - |
G-361 cell | the redox dye 2,6-dichlorophenolindophenol may serve as a prooxidant chemotherapeutic targeting human melanoma cells in vitro and in vivo. DCPIP-apoptogenicity observed in the human melanoma cell lines A375 and G361 is inversely correlated with NAD(P)H:quinone oxidoreductase (NQO1) expression levels. 2,6-Dichlorophenolindophenol apoptogenic potency observed in human A375 and G361 melanoma cells is a function of cellular NQO1 expression levels | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H:quinone oxidoreductase | - |
Homo sapiens |
NQO1 | - |
Homo sapiens |