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Literature summary for 1.6.5.2 extracted from

  • Douglas, M.; Lim, A.R.; Porter, J.R.; West, K.; Pink, M.M.; Ge, J.; Wylie, A.A.; Tibbits, T.T.; Biggs, K.; Curtis, M.; Palombella, V.J.; Adams, J.; Fritz, C.C.; Normant, E.
    The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo (2009), Mol. Cancer Ther., 8, 3369-3378.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
Homo sapiens
-
A-549 cell
-
Homo sapiens
-
AsPC-1 cell
-
Homo sapiens
-
BT-474 cell
-
Homo sapiens
-
DAUDI cell
-
Homo sapiens
-
HCC-827 cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
IGROV-1 cell
-
Homo sapiens
-
JIMT-1 cell
-
Homo sapiens
-
L3.6pl cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
additional information NQO1 is not detected in the acute myelogenous leukemia cell line MV4:11 or in the non-small cell lung cancer cell line HCC-4006 Homo sapiens
-
NCI-H1650 cell
-
Homo sapiens
-
NCI-H1975 cell
-
Homo sapiens
-
NCI-H460 cell
-
Homo sapiens
-
SK-BR-3 cell
-
Homo sapiens
-
SKOV-3 cell
-
Homo sapiens
-
SW-480 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menadione + NADH
-
Homo sapiens reduced menadione + NAD+
-
?

Synonyms

Synonyms Comment Organism
NAD(P)H:quinone oxidoreductase 1
-
Homo sapiens
NQO1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
physiological function artificial overexpression of NQO1 is able to increase the level of hydroquinone and cell sensitivity to IPI-504. NQO1 activity is not a determinant of IPI-504 activity Homo sapiens