Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dicoumarol | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | - |
Homo sapiens | - |
A-549 cell | - |
Homo sapiens | - |
AsPC-1 cell | - |
Homo sapiens | - |
BT-474 cell | - |
Homo sapiens | - |
DAUDI cell | - |
Homo sapiens | - |
HCC-827 cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
IGROV-1 cell | - |
Homo sapiens | - |
JIMT-1 cell | - |
Homo sapiens | - |
L3.6pl cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
additional information | NQO1 is not detected in the acute myelogenous leukemia cell line MV4:11 or in the non-small cell lung cancer cell line HCC-4006 | Homo sapiens | - |
NCI-H1650 cell | - |
Homo sapiens | - |
NCI-H1975 cell | - |
Homo sapiens | - |
NCI-H460 cell | - |
Homo sapiens | - |
SK-BR-3 cell | - |
Homo sapiens | - |
SKOV-3 cell | - |
Homo sapiens | - |
SW-480 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
menadione + NADH | - |
Homo sapiens | reduced menadione + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD(P)H:quinone oxidoreductase 1 | - |
Homo sapiens |
NQO1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | artificial overexpression of NQO1 is able to increase the level of hydroquinone and cell sensitivity to IPI-504. NQO1 activity is not a determinant of IPI-504 activity | Homo sapiens |