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Literature summary for 1.7.1.9 extracted from
- Conversion of 4-nitroquinoline 1-oxide (4NQO) to 4-hydroxyaminoquinoline 1-oxide by a dicumarol-resistant hepatic 4NQO nitroreductase in rats and mice (1993), Biochem. Pharmacol., 46, 1217-1221.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by dicoumarol | Mus musculus | |
| additional information | not inhibited by 0.015 mM dicoumarol | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitroquinoline N-oxide + NAD(P)H + H+ | NADH is preferred, 15% activity with NADPH | Rattus norvegicus | 4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O | - |
? |  |
| 4-nitroquinoline N-oxide + NAD(P)H + H+ | strong preference for NADH | Mus musculus | 4-(hydroxyamino)quinoline N-oxide + NAD(P)+ + H2O | - |
? | |
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