Literature summary for 1.7.2.2 extracted from

Bykov, D.; Neese, F.
Reductive activation of the heme iron-nitrosyl intermediate in the reaction mechanism of cytochrome c nitrite reductase: a theoretical study (2012), J. Biol. Inorg. Chem., 17, 741-760.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Calcium	the highly conserved calcium located in the direct proximity of the active site plays an important role in the substrate conversion through the facilitation of the proton transfer steps	Wolinella succinogenes

Organism

Organism	UniProt	Comment	Textmining
Wolinella succinogenes	Q9S1E5	-	-
Wolinella succinogenes ATCC 29543	Q9S1E5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	simulation of the kinetics of the reduction process reveals that the complex recharging process can be accomplished in two possible ways: either through two consecutive proton-coupled electron transfers or in the form of three consecutive elementary steps involving reduction, proton-coupled electron transfers and protonation. Recharging through two proton-coupled electron transfers is a means of overcoming the predicted deep energetic minimum that is calculated to occur at the stage of the Fe(II)-NO radical intermediate. The radical transfer role for the active-site Tyr218, cannot be confirmed. The highly conserved calcium located in the direct proximity of the active site plays an important role in the substrate conversion through the facilitation of the proton transfer steps	Wolinella succinogenes	?	-	?
additional information	simulation of the kinetics of the reduction process reveals that the complex recharging process can be accomplished in two possible ways: either through two consecutive proton-coupled electron transfers or in the form of three consecutive elementary steps involving reduction, proton-coupled electron transfers and protonation. Recharging through two proton-coupled electron transfers is a means of overcoming the predicted deep energetic minimum that is calculated to occur at the stage of the Fe(II)-NO radical intermediate. The radical transfer role for the active-site Tyr218, cannot be confirmed. The highly conserved calcium located in the direct proximity of the active site plays an important role in the substrate conversion through the facilitation of the proton transfer steps	Wolinella succinogenes ATCC 29543	?	-	?

Synonyms

Synonyms	Comment	Organism
WS0969	locus name	Wolinella succinogenes

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Release 2023.1 (January 2023)