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Literature summary for 1.7.2.3 extracted from
- Structure of the molybdenum site of Escherichia coli trimethylamine N-oxide reductase (2008), Inorg. Chem., 47, 1074-1078.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Molybdenum | involved in the catalytic mechanism, experimental data suggest that the active site of TMAO reductase with bound molybdenum can exist in three different forms | Escherichia coli |  |
| molybdopterin | in the molybdopterin molybdenum cofactor, Mo-S and Mo-O interactions, molecular structure modelling, overview | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trimethylamine-N-oxide + enzyme-MoIV | Escherichia coli | anaerobic respiration | trimethylamine + enzyme-MoVI + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+ | molybdenum serves as electron donor within the enzyme, enzyme-MoIV + (CH3)3NdO + 2H+ = enzyme-MoVI + (CH3)3N + H2O | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the TMAO reductase active site can exist in multiple forms, molecular modelling, overview | Escherichia coli | ? | - |
? | |
| trimethylamine-N-oxide + enzyme-MoIV | anaerobic respiration | Escherichia coli | trimethylamine + enzyme-MoVI + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | structure comparison and analysis, the TMAO reductase active site can exist in multiple forms, molecular modelling, overview | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TMAO reductase | - |
Escherichia coli |
| TMAO reductase | belongs to the DMSO reductase family of molybdenum enzymes | Escherichia coli |
| trimethylamine N-oxide reductase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| molybdopterin | - |
Escherichia coli | |
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