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Literature summary for 1.8.1.12 extracted from

  • Taylor, M.C.; Chapman, C.J.; Kelly, J.M.; Fairlamb, A.H.; Miles, M.A.
    Cloning by expression of a cDNA corresponding to Leishmania donovani trypanothione reductase (1989), Biochem. Soc. Trans., 17, 579-580.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma brucei
additional information activity is dependent on a redox-active cysteine at the active centre Crithidia fasciculata
additional information activity is dependent on a redox-active cysteine at the active centre Leishmania donovani
additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma cruzi
additional information activity is dependent on a redox-active cysteine at the active centre Trypanosoma congolense
additional information activity is dependent on a redox-active cysteine at the active centre Leishmania aethiopica

Cloned(Commentary)

Cloned (Comment) Organism
single copy gene Leishmania donovani

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
-
insect-parasitic trypanosomatid
-
Leishmania aethiopica
-
-
-
Leishmania donovani
-
-
-
Trypanosoma brucei
-
-
-
Trypanosoma congolense
-
-
-
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Trypanosoma brucei trypanothione + NADP+
-
r
trypanothione disulfide + NADPH
-
Crithidia fasciculata trypanothione + NADP+
-
r
trypanothione disulfide + NADPH
-
Leishmania donovani trypanothione + NADP+
-
r
trypanothione disulfide + NADPH
-
Trypanosoma cruzi trypanothione + NADP+
-
r
trypanothione disulfide + NADPH
-
Trypanosoma congolense trypanothione + NADP+
-
r
trypanothione disulfide + NADPH
-
Leishmania aethiopica trypanothione + NADP+
-
r

Subunits

Subunits Comment Organism
? x * 50000-55000, SDS-PAGE, immunostaining Trypanosoma brucei
? x * 50000-55000, SDS-PAGE, immunostaining Crithidia fasciculata
? x * 50000-55000, SDS-PAGE, immunostaining Leishmania donovani
? x * 50000-55000, SDS-PAGE, immunostaining Trypanosoma cruzi
? x * 50000-55000, SDS-PAGE, immunostaining Leishmania aethiopica

Cofactor

Cofactor Comment Organism Structure
FAD
-
Trypanosoma brucei
FAD
-
Crithidia fasciculata
FAD
-
Leishmania donovani
FAD
-
Trypanosoma cruzi
FAD
-
Trypanosoma congolense
FAD
-
Leishmania aethiopica
NADP+
-
Trypanosoma brucei
NADP+
-
Crithidia fasciculata
NADP+
-
Leishmania donovani
NADP+
-
Trypanosoma cruzi
NADP+
-
Trypanosoma congolense
NADP+
-
Leishmania aethiopica
NADPH
-
Trypanosoma brucei
NADPH
-
Crithidia fasciculata
NADPH
-
Leishmania donovani
NADPH
-
Trypanosoma cruzi
NADPH
-
Trypanosoma congolense
NADPH
-
Leishmania aethiopica