Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma brucei | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Leishmania donovani | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma congolense | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Leishmania aethiopica |
Cloned (Comment) | Organism |
---|---|
single copy gene | Leishmania donovani |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
Leishmania aethiopica | - |
- |
- |
Leishmania donovani | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Trypanosoma congolense | - |
- |
- |
Trypanosoma cruzi | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma brucei | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Leishmania donovani | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Trypanosoma congolense | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | - |
Leishmania aethiopica | trypanothione + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000-55000, SDS-PAGE, immunostaining | Trypanosoma brucei |
? | x * 50000-55000, SDS-PAGE, immunostaining | Crithidia fasciculata |
? | x * 50000-55000, SDS-PAGE, immunostaining | Leishmania donovani |
? | x * 50000-55000, SDS-PAGE, immunostaining | Trypanosoma cruzi |
? | x * 50000-55000, SDS-PAGE, immunostaining | Leishmania aethiopica |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma brucei | |
FAD | - |
Crithidia fasciculata | |
FAD | - |
Leishmania donovani | |
FAD | - |
Trypanosoma cruzi | |
FAD | - |
Trypanosoma congolense | |
FAD | - |
Leishmania aethiopica | |
NADP+ | - |
Trypanosoma brucei | |
NADP+ | - |
Crithidia fasciculata | |
NADP+ | - |
Leishmania donovani | |
NADP+ | - |
Trypanosoma cruzi | |
NADP+ | - |
Trypanosoma congolense | |
NADP+ | - |
Leishmania aethiopica | |
NADPH | - |
Trypanosoma brucei | |
NADPH | - |
Crithidia fasciculata | |
NADPH | - |
Leishmania donovani | |
NADPH | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma congolense | |
NADPH | - |
Leishmania aethiopica |