Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma brucei | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
Application | Comment | Organism |
---|---|---|
medicine | - |
Crithidia fasciculata |
medicine | enzyme substrate trypanothione disulfide is the primary target for arsenical drugs against african trypanosomes | Trypanosoma brucei |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
melarsen-trypanothione disulfide adduct | i.e. adduct of p-(4,6-diamino-S-triazinyl-2-yl)aminophenyl arsenoxide with N1,N8-bis-(glutathionyl)spermidine | Crithidia fasciculata | |
melarsen-trypanothione disulfide adduct | i.e. adduct of p-(4,6-diamino-S-triazinyl-2-yl)aminophenyl arsenoxide with N1,N8-bis-(glutathionyl)spermidine | Trypanosoma brucei | |
melarsen-trypanothione disulfide-adduct | - |
Crithidia fasciculata | |
melarsen-trypanothione disulfide-adduct | - |
Trypanosoma brucei |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.053 | - |
trypanothione disulfide | - |
Crithidia fasciculata | |
0.058 | - |
trypanothione disulfide | - |
Trypanosoma brucei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Trypanosoma brucei | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | Crithidia fasciculata | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma brucei | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | trypanothione is the oxidized form of N1,N8-bis-(glutathionyl)spermidine, the latter form a stable adduct with melarsen oxide | Trypanosoma brucei | trypanothione + NADP+ | - |
r | |
trypanothione disulfide + NADPH | trypanothione is the oxidized form of N1,N8-bis-(glutathionyl)spermidine, the latter form a stable adduct with melarsen oxide | Crithidia fasciculata | trypanothione + NADP+ | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma brucei | |
FAD | - |
Crithidia fasciculata | |
NADPH | - |
Trypanosoma brucei | |
NADPH | - |
Crithidia fasciculata |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
melarsen-trypanothione disulfide-adduct | - |
Trypanosoma brucei | |
0.036 | - |
melarsen-trypanothione disulfide-adduct | - |
Crithidia fasciculata |