Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iodoacetamide | inhibition only of the enzyme with reduced cysteine residues in the catalytic center by alkylation | Crithidia fasciculata |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | 0.007 | NADPH | - |
Crithidia fasciculata | |
0.053 | - |
trypanothione disulfide | - |
Crithidia fasciculata |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53800 | - |
1 * 53800, SDS-PAGE | Crithidia fasciculata |
110000 | - |
enzyme cross-linked with dimethyl suberimidate, SDS-PAGE | Crithidia fasciculata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Crithidia fasciculata | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
Purification (Comment) | Organism |
---|---|
- |
Crithidia fasciculata |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
284 | - |
purified enzyme | Crithidia fasciculata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | highly specific for | Crithidia fasciculata | trypanothione + NADP+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 53800, SDS-PAGE | Crithidia fasciculata |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
517 | - |
trypanothione disulfide | - |
Crithidia fasciculata |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | trypanothione disulfide + NADPH | Crithidia fasciculata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Crithidia fasciculata | |
NADPH | - |
Crithidia fasciculata |