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Literature summary for 1.8.1.12 extracted from

  • Lee, B.; Bauer, H.; Melchers, J.; Ruppert, T.; Rattray, L.; Yardley, V.; Davioud-Charvet, E.; Krauth-Siegel, R.L.
    Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate (2005), J. Med. Chem., 48, 7400-7410.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1E)-1-(2-chlorophenyl)penta-1,4-dien-3-one 0.1 mM, irreversible inhibition Trypanosoma cruzi
(4E)-5-(2-chlorophenyl)-N,N,2,2-tetramethyl-3-oxopent-4-en-1-aminium chloride 0.1 mM, reversible inhibition Trypanosoma cruzi
(4E)-5-(2-chlorophenyl)-N,N-dimethyl-3-oxopent-4-en-1-aminium chloride 0.1 mM, irreversible inhibition Trypanosoma cruzi
1-[(4E)-5-(2-chlorophenyl)-3-oxopent-4-en-1-yl]piperidinium chloride 0.1 mM, irreversible inhibition Trypanosoma cruzi
4-(2-chlorobenzyl)cyclopent-2-en-1-one 0.1 mM, reversible inhibition Trypanosoma cruzi
4-[(4E)-5-(2-chlorophenyl)-3-oxopent-4-en-1-yl]morpholin-4-ium chloride 0.1 mM, irreversible inhibition Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
Trypanosoma cruzi trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
TR
-
Trypanosoma cruzi
trypanothione reductase
-
Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Trypanosoma cruzi