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Literature summary for 1.8.1.12 extracted from

  • Cota, B.B.; Rosa, L.H.; Caligiorne, R.B.; Rabello, A.L.; Almeida Alves, T.M.; Rosa, C.A.; Zani, C.L.
    Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp., inhibits trypanothione reductase from Trypanosoma cruzi (2008), FEMS Microbiol. Lett., 285, 177-182.
    View publication on PubMed
Search for more literature for 1.8.1.12

Inhibitors

Inhibitors Comment Organism Structure
altenusin no inhibitory activity on viability of amastigotes Leishmania amazonensis
altenusin a biphenyl isolated from the endophytic fungus Alternaria sp. Trypanosoma cruzi
alternariol no inhibitory activity Trypanosoma cruzi
alternariol methyl ether no inhibitory activity Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Leishmania amazonensis
-
 amastigote
-
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid)
-
 Trypanosoma cruzi trypanothione disulfide + thionitrobenzoate
-
 ?
trypanothione + 5,5'-dithiobis-(2-nitrobenzoic acid)
-
 Leishmania amazonensis trypanothione disulfide + thionitrobenzoate
-
 ?
trypanothione + NADP+
-
 Trypanosoma cruzi trypanothione disulfide + NADPH + H+
-
 ?
trypanothione + NADP+
-
 Leishmania amazonensis trypanothione disulfide + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
trypanothione reductase TR Trypanosoma cruzi
trypanothione reductase TR Leishmania amazonensis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0043
-
-
 Trypanosoma cruzi altenusin