Literature summary for 1.8.1.12 extracted from

Castro-Pinto, D.B.; Lima, E.L.; Cunha, A.S.; Genestra, M.; De Leo, R.M.; Monteiro, F.; Leon, L.L.
Leishmania amazonensis trypanothione reductase: evaluation of the effect of glutathione analogs on parasite growth, infectivity and enzyme activity (2007), J. Enzyme Inhib. Med. Chem., 22, 71-75.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Leu-Ala	glutathione analogue, ASC-I-74B, inhibition of parasite growth and trypanothione reductase activity	Leishmania amazonensis
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Leu-Gly	glutathione analogue, ASC-I-74A, inhibition of parasite growth and trypanothione reductase activity	Leishmania amazonensis
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Val-Ala	glutathione analogue, ASC-I-75B, inhibition of parasite growth and trypanothione reductase activity	Leishmania amazonensis
N-benzyolxycarbonyl-L-glutamyl(-benzoyl)-L-Val-Gly	glutathione analogue, ASC-I-75A, inhibition of parasite growth and trypanothione reductase activity	Leishmania amazonensis

Organism

Organism	UniProt	Comment	Textmining
Leishmania amazonensis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trypanothione + NADP+	parasite soluble fraction	Leishmania amazonensis	trypanothione disulfide + NADPH + H+	-	?

Synonyms

Synonyms	Comment	Organism
trypanothione reductase	TR	Leishmania amazonensis

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Release 2023.1 (January 2023)