Literature summary for 1.8.1.12 extracted from

Eberle, C.; Lauber, B.S.; Fankhauser, D.; Kaiser, M.; Brun, R.; Krauth-Siegel, R.L.; Diederich, F.
Improved inhibitors of trypanothione reductase by combination of motifs: synthesis, inhibitory potency, binding mode, and antiprotozoal activities (2011), ChemMedChem, 6, 292-301.

Inhibitors

Inhibitors	Comment	Organism
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine	-	Leishmania donovani
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine	-	Plasmodium falciparum
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine	-	Trypanosoma brucei rhodesiense
1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine	36% inhibition at 0.1 mM	Trypanosoma cruzi
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine	-	Leishmania donovani
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine	-	Plasmodium falciparum
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine	-	Trypanosoma brucei rhodesiense
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine	-	Trypanosoma cruzi
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine	-	Leishmania donovani
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine	-	Plasmodium falciparum
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine	-	Trypanosoma brucei rhodesiense
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine	-	Trypanosoma cruzi
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine	-	Leishmania donovani
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine	-	Plasmodium falciparum
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine	-	Trypanosoma brucei rhodesiense
1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)piperidine	-	Trypanosoma cruzi
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate	-	Leishmania donovani
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate	-	Plasmodium falciparum
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate	-	Trypanosoma brucei rhodesiense
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate	86% inhibition at 0.04 mM	Trypanosoma cruzi
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate	-	Leishmania donovani
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate	-	Plasmodium falciparum
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate	-	Trypanosoma brucei rhodesiense
1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate	52% inhibition at 0.04 mM	Trypanosoma cruzi
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine	-	Leishmania donovani
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine	-	Plasmodium falciparum
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine	-	Trypanosoma brucei rhodesiense
1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine	16% inhibition at 0.1 mM	Trypanosoma cruzi
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine	-	Leishmania donovani
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine	-	Plasmodium falciparum
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine	-	Trypanosoma brucei rhodesiense
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine	28% inhibition at 0.1 mM	Trypanosoma cruzi
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine	-	Leishmania donovani
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine	-	Plasmodium falciparum
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine	-	Trypanosoma brucei rhodesiense
1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine	28% inhibition at 0.1 mM	Trypanosoma cruzi
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine	-	Leishmania donovani
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine	-	Plasmodium falciparum
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine	-	Trypanosoma brucei rhodesiense
1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine	25% inhibition at 0.1 mM	Trypanosoma cruzi
2-(1-cyclopentylcyclohexyl)-1-benzothiophene	-	Leishmania donovani
2-(1-cyclopentylcyclohexyl)-1-benzothiophene	-	Plasmodium falciparum
2-(1-cyclopentylcyclohexyl)-1-benzothiophene	-	Trypanosoma brucei rhodesiense
2-(1-cyclopentylcyclohexyl)-1-benzothiophene	61% inhibition at 0.04 mM	Trypanosoma cruzi
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	-	Leishmania donovani
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	-	Plasmodium falciparum
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	-	Trypanosoma brucei rhodesiense
2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	58% inhibition at 0.1 mM	Trypanosoma cruzi
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	-	Leishmania donovani
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	-	Plasmodium falciparum
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	-	Trypanosoma brucei rhodesiense
2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline	42% inhibition at 0.1 mM	Trypanosoma cruzi
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine	-	Leishmania donovani
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine	-	Plasmodium falciparum
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine	-	Trypanosoma brucei rhodesiense
N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine	46% inhibition at 0.1 mM	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Leishmania donovani	-	-	-
Plasmodium falciparum	-	-	-
Trypanosoma brucei rhodesiense	-	-	-
Trypanosoma cruzi	P28593	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
trypanothione disulfide + NADPH + H+	-	Leishmania donovani	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Plasmodium falciparum	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Trypanosoma brucei rhodesiense	trypanothione + NADP+	-	?
trypanothione disulfide + NADPH + H+	-	Trypanosoma cruzi	trypanothione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
trypanothione reductase	-	Leishmania donovani
trypanothione reductase	-	Plasmodium falciparum
trypanothione reductase	-	Trypanosoma brucei rhodesiense
trypanothione reductase	-	Trypanosoma cruzi

Cofactor

Cofactor	Comment	Organism
FAD	-	Leishmania donovani
FAD	-	Plasmodium falciparum
FAD	-	Trypanosoma brucei rhodesiense
FAD	-	Trypanosoma cruzi
NADPH	-	Leishmania donovani
NADPH	-	Plasmodium falciparum
NADPH	-	Trypanosoma brucei rhodesiense
NADPH	-	Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism
0.0011	-	1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine	at 25°C, pH not specified in the publication	Trypanosoma cruzi
0.002	-	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate	at 25°C, pH not specified in the publication	Trypanosoma cruzi
0.005	-	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate	at 25°C, pH not specified in the publication	Trypanosoma cruzi

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00009	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
0.00012	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
0.00013	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
0.00023	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
0.00023	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
0.00028	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
0.00032	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
0.00039	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
0.00082	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.00088	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.00088	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
0.0011	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
0.0013	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
0.0016	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
0.00173	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
0.00186	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
0.00211	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
0.00233	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-4-yl)methyl)piperazine
0.0024	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-(3,4-dichlorobenzyl)-N,N-dimethylmethanaminium formate
0.00253	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
0.00323	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
0.00327	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.00401	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
0.00424	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-4-yl]methyl)piperazine
0.00458	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
0.00627	-	at 25°C, pH not specified in the publication	Plasmodium falciparum	2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.00633	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-(2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)-N-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-N,N-dimethylmethanaminium formate
0.00656	-	at 25°C, pH not specified in the publication	Leishmania donovani	N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
0.0106	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
0.0116	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	N-([2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-N-ethylethanamine
0.0122	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
0.0239	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
0.025	-	at 25°C, pH not specified in the publication	Trypanosoma brucei rhodesiense	1-[1-(1-benzothiophen-2-yl)cyclohexyl]-4-([1-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-1,2,3-triazol-4-yl]methyl)piperazine
0.0337	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-[2-[2,6-bis(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]-N,N-dimethylmethanamine
0.05212	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-(1-(benzo[b]thiophen-2-yl)cyclohexyl)-4-((1-(2,6-bis(phenylthio)phenyl)-1H-1,2,3-triazol-4-yl)methyl)piperazine
0.0539	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.0759	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine
0.112	-	at 25°C, pH not specified in the publication	Leishmania donovani	2-[5-[(4-methylpiperazin-1-yl)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.115	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	1-((2-(2,6-bis(phenylthio)phenyl)-1H-imidazol-5-yl)methyl)-4-methylpiperazine
0.162	-	at 25°C, pH not specified in the publication	Trypanosoma cruzi	2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.18	-	at 25°C, pH not specified in the publication	Leishmania donovani	2-[5-[(dimethylamino)methyl]-1H-imidazol-2-yl]-N-phenyl-3-(phenylsulfanyl)aniline
0.194	-	at 25°C, pH not specified in the publication	Leishmania donovani	1-([2-[5-bromo-2-(phenylsulfanyl)phenyl]-1H-imidazol-5-yl]methyl)-4-methylpiperazine