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Literature summary for 1.8.1.4 extracted from
- Extramitochondrial reduction of ubiquinone by flavoenzymes (2004), Methods Enzymol., 378, 131-138.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Sus scrofa | 5829 | - |
| microsome | - |
Sus scrofa | - |
- |
| mitochondrion | enzyme is part of multienzyme complexes in the inner mitochondrial membrane | Sus scrofa | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | highly activating ubiquinone reduction, up to 0.5 mM | Sus scrofa |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
2 * 55000 | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ubiquinone-10 + NAD(P)H | Sus scrofa | reaction is important to protect the cell e.g. from oxidative stress | ubiquinol-10 + NAD(P)+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell culture | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ubiquinone-10 + NAD(P)H | - |
Sus scrofa | ubiquinol-10 + NAD(P)+ | - |
? | |
| ubiquinone-10 + NAD(P)H | reaction is important to protect the cell e.g. from oxidative stress | Sus scrofa | ubiquinol-10 + NAD(P)+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 55000 | Sus scrofa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DT-diaphorase | - |
Sus scrofa |
| lipoamide dehydrogenase | - |
Sus scrofa |
| More | enzyme belongs to the family of pyridine nucleotide oxidoreductases | Sus scrofa |
| ubiquinone reductase | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme prefers acidic pH | Sus scrofa |
| 7.5 | - |
assay at | Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | 8 | - |
Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | the enzyme contains 1 functionally important FAD per subunit | Sus scrofa | |
| additional information | the enzyme contains 1 disulfide/dithiol per subunit | Sus scrofa | |
| NAD(P)H | NADPH and NADH are utilized at similar rates for ubiquinone reduction | Sus scrofa | |
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Release 2023.1 (January 2023)
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