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Literature summary for 1.8.1.4 extracted from

  • Kim, S.Y.; Kim, J.
    Roles of dihydrolipoamide dehydrogenase Lpd1 in Candida albicans filamentation (2010), Fungal Genet. Biol., 47, 782-788.
    View publication on PubMed
Search for more literature for 1.8.1.4

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion Lpd1 protein is localized in the mitochondria during the logarithmic yeast growth and the filamentous growth Candida albicans 5739
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Organism

Organism UniProt Comment Textmining
Candida albicans
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-
-
Candida albicans CAI-4
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrolipoamide + NAD+
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 Candida albicans lipoamide + NADH
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 ?
dihydrolipoamide + NAD+
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 Candida albicans CAI-4 lipoamide + NADH
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 ?

Synonyms

Synonyms Comment Organism
LPD1
-
 Candida albicans

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Candida albicans
NAD+
-
 Candida albicans

General Information

General Information Comment Organism
malfunction the homozygous deletion mutant lpd1/lpd1 is unable to grow on non-fermentable carbon sources including glycerol, ethanol, acetate, and citrate. In addition, the lpd1/lpd1 strain exhibits a slow-growth phenotype on glucose-containing media and a marked sensitivity to 0.5 mM of hydrogen peroxide and shows filamentation defects Candida albicans
physiological function dihydrolipoamide dehydrogenase Lpd1 is a catalytic component of pyruvate dehydrogenase complex. LPD1 is required for filamentous growth under a serum-containing hyphal-inducing condition Candida albicans