Literature summary for 1.8.1.6 extracted from

Ondarza, R.N.; Iturbe, A.; Hernandez, E.
The effects by neuroleptics, antimycotics and antibiotics on disulfide reducing enzymes from the human pathogens Acanthamoeba polyphaga and Naegleria fowleri (2007), Exp. Parasitol., 115, 41-47.

Search for more literature for 1.8.1.6

Activating Compound

Activating Compound	Comment	Organism	Structure
amphotericin	29% enhancement of activity at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
Mepacrine	56% enhancement of activity at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
metronidazole	4fold stimulation at a concentration of 0.032 mg/ml	Naegleria fowleri
rifampicin	147% enhancement of activity at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga

Inhibitors

Inhibitors	Comment	Organism	Structure
amphotericin	100% inhibition at a concentration of 0.032 mg/ml	Naegleria fowleri
chlorpromazine	100% inhibition at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
chlorpromazine	100% inhibition at a concentration of 0.032 mg/ml	Naegleria fowleri
ketoconazole	100% inhibition at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
Mepacrine	100% inhibition at a concentration of 0.032 mg/ml	Naegleria fowleri
metronidazole	26% inhibition at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
miconazole	100% inhibition at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
miconazole	100% inhibition at a concentration of 0.032 mg/ml	Naegleria fowleri
Pentamidine	58% inhibition at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
trifluoroperazine	100% inhibition at a concentration of 0.032 mg/ml	Acanthamoeba polyphaga
trifluoroperazine	100% inhibition at a concentration of 0.032 mg/ml	Naegleria fowleri

Organism

Organism	UniProt	Comment	Textmining
Acanthamoeba polyphaga	-	-	-
Naegleria fowleri	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADH + L-cystine + H+	-	Naegleria fowleri	NAD+ + L-cysteine	-	?
NADH + L-cystine + H+	-	Acanthamoeba polyphaga	NAD+ + L-cysteine	-	?

Synonyms

Synonyms	Comment	Organism
CysR	-	Naegleria fowleri
CysR	-	Acanthamoeba polyphaga

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Release 2023.1 (January 2023)