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Literature summary for 1.8.1.7 extracted from

  • Malaisse, W.J.; Dufrane, S.P.; Mathias, P.C.F.; Carpinelli, A.R.; Malaisse-Lagae, F.; Garcia-Morales, P.; Valverde, I.; Sener, A.
    The coupling of metabolic to secretory events in pancreatic islets. The possible role of glutathione reductase (1985), Biochim. Biophys. Acta, 844, 256-264.
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
1,3-Bis-(2-chloroethyl)-1-nitrosourea time- and dose-dependent irreversible inhibition Rattus norvegicus
p-hydroxymercuribenzoate
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GSSG + NADPH Rattus norvegicus enzyme plays a key role in nutrient-induced increase in the thiol content of pancreatic-islet cells and this increase itself participates in the coupling of metabolic to secretory events glutathione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreatic islet
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSSG + NADPH
-
 Rattus norvegicus glutathione + NADP+
-
 ?
GSSG + NADPH enzyme plays a key role in nutrient-induced increase in the thiol content of pancreatic-islet cells and this increase itself participates in the coupling of metabolic to secretory events Rattus norvegicus glutathione + NADP+
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus