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Literature summary for 1.8.1.7 extracted from

  • Carlberg, I.; Mannervik, B.
    Purification and characterization of the flavoenzyme glutathione reductase from rat liver (1975), J. Biol. Chem., 250, 5475-5480.
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
NADP+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
 2 * 60000, SDS-PAGE Rattus norvegicus
125000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
207
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSSG + NADPH
-
 Rattus norvegicus glutathione + NADP+
-
 ?
additional information branched mechanism Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 60000, SDS-PAGE Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 5.5 NADH + GSSG Rattus norvegicus
7
-
 NADPH + GSSG Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD 2 mol of FAD per mol of enzyme Rattus norvegicus
additional information no activity with FMN Rattus norvegicus
NADH 10% activity of that with NADPH Rattus norvegicus