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Literature summary for 1.8.1.7 extracted from

  • Rice, K.P.; Penketh, P.G.; Shyam, K.; Sartorelli, A.C.
    Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU (2005), Biochem. Pharmacol., 69, 1463-1472.
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
1,2-bis[methylsulfonyl]-1-[2-[chloroethyl]-2-(methylamino)carbonyl]hydrazine 0.05 mM, 28% inhibition Mus musculus
1,3-bis[2-chloroethyl]-2-nitrosourea 0.05 mM, 84% inhibition Homo sapiens
1,3-bis[2-chloroethyl]-2-nitrosourea 0.05 mM, 94% inhibition Mus musculus
additional information no inhibition by 1,2-bis[methylsulfonyl]-1-[2-[chloroethyl]-2 ](methylamino)carbonyl hydrazine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
L-1210 cell
-
 Mus musculus
-
leukemia cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Mus musculus glutathione + NADP+
-
 ?
glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Mus musculus
glutathione reductase
-
 Homo sapiens
GR
-
 Mus musculus
GR
-
 Homo sapiens