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Literature summary for 1.8.1.7 extracted from

  • Lalaouni, A.; Henderson, C.; Kupper, C.; Grant, M.H.
    The interaction of chromium (VI) with macrophages: depletion of glutathione and inhibition of glutathione reductase (2007), Toxicology, 236, 76-81.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Cr6+ during the metabolism of Cr VI, glutathione reductase activity is inhibited Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens prior inhibition of glutathione reductase activity protects against the toxicity of Cr6+ to a significant extent, suggesting that it reduces Cr6+ to a toxic metabolite ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information prior inhibition of glutathione reductase activity protects against the toxicity of Cr6+ to a significant extent, suggesting that it reduces Cr6+ to a toxic metabolite Homo sapiens ?
-
?