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Literature summary for 1.8.1.7 extracted from

  • Arning, J.; Dringen, R.; Schmidt, M.; Thiessen, A.; Stolte, S.; Matzke, M.; Bottin-Weber, U.; Caesar-Geertz, B.; Jastorff, B.; Ranke, J.
    Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2 (2008), Toxicology, 246, 203-212.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
4,5-dichloro-N-octylisothiazol-3-one
-
 Homo sapiens
5-chloro-N-methylisothiazol-3-one
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.009
-
 cellular glutathione reductase Homo sapiens 5-chloro-N-methylisothiazol-3-one
0.014
-
 cellular glutathione reductase Homo sapiens 4,5-dichloro-N-octylisothiazol-3-one