Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diclofenac sodium | competitive inhibition | Homo sapiens | |
etomidate | competitive inhibition | Homo sapiens | |
Ketoprofen | competitive inhibition | Homo sapiens | |
lornoxicam | competitive inhibition | Homo sapiens | |
morphine | competitive inhibition | Homo sapiens | |
propofol | noncompetitive inhibition | Homo sapiens | |
tenoxicam | competitive inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, 2',5'-ADP Sepharose 4B column chromatography and Sephadex G-200 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0097 | - |
hemolysate, at 25°C, pH 8.0 | Homo sapiens |
20.75 | - |
after 2139fold purification, at 25°C, pH 8.0 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
glutathione reductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0165 | - |
morphine | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
0.0725 | - |
etomidate | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
0.13 | - |
tenoxicam | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
0.418 | - |
propofol | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
0.42 | - |
lornoxicam | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
22.14 | - |
Ketoprofen | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
23.97 | - |
diclofenac sodium | in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0128 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | morphine | |
0.0523 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | etomidate | |
0.082 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | tenoxicam | |
0.242 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | propofol | |
0.3 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | lornoxicam | |
6.278 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | Ketoprofen | |
7.265 | - |
in 100 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | diclofenac sodium |