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Literature summary for 1.8.1.9 extracted from

  • Maggioli, G.; Piacenza, L.; Carambula, B.; Carmona, C.
    Purification, characterization, and immunolocalization of a thioredoxin reductase from adult (2004), J. Parasitol., 90, 205-211.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
FADH2 activates Fasciola hepatica

Inhibitors

Inhibitors Comment Organism Structure
aurothioglucose IC50: 120 nM Fasciola hepatica

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenoenzyme Fasciola hepatica

Organism

Organism UniProt Comment Textmining
Fasciola hepatica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Fasciola hepatica

Source Tissue

Source Tissue Comment Organism Textmining
additional information not found in tegument of adult fluke Fasciola hepatica
-
parenchyma
-
Fasciola hepatica
-
testis
-
Fasciola hepatica
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Fasciola hepatica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
-
Fasciola hepatica 2-nitro-5-thiobenzoate + NADP+
-
?

Synonyms

Synonyms Comment Organism
TrxR
-
Fasciola hepatica

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Fasciola hepatica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00012
-
IC50: 120 nM Fasciola hepatica aurothioglucose