Application | Comment | Organism |
---|---|---|
medicine | development of novel anticancer agents | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
palmarumycin CP1 | 0.001 mM, the naphthoquinone spiroketal fungal metabolite palmarumycin CP1 is a potent inhibitor of thioredoxin reductase-1, IC50: 0.00035 mM | Homo sapiens | |
PX-911 | 0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.0032 mM | Homo sapiens | |
PX-916 | 0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, potent inhibitor of purified human thioredoxin reductase-1, IC50: 0.00028 mM | Homo sapiens | |
PX-960 | 0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.00027 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | 0.001 mM, 5fold increase of activity after 7 days | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
rhabdomyosarcoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH | - |
Homo sapiens | 2-nitro-5-thiobenzoate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NADPH-dependent thioredoxin reductase-1 | - |
Homo sapiens |
thioredoxin reductase | - |
Homo sapiens |
TrxR | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00027 | - |
0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.00027 mM | Homo sapiens | PX-960 | |
0.00028 | - |
0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, potent inhibitor of purified human thioredoxin reductase-1, IC50: 0.00028 mM | Homo sapiens | PX-916 | |
0.00035 | - |
0.001 mM, the naphthoquinone spiroketal fungal metabolite palmarumycin CP1 is a potent inhibitor of thioredoxin reductase-1, IC50: 0.00035 mM | Homo sapiens | palmarumycin CP1 | |
0.0032 | - |
0.001 mM, a water-soluble prodrug of a palmarumycin CP1 analogue, IC50: 0.0032 mM | Homo sapiens | PX-911 |