Literature summary for 1.8.1.9 extracted from

Omata, Y.; Folan, M.; Shaw, M.; Messer, R.L.; Lockwood, P.E.; Hobbs, D.; Bouillaguet, S.; Sano, H.; Lewis, J.B.; Wataha, J.C.
Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1) (2006), Toxicol. In Vitro, 20, 882-890.

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Inhibitors

Inhibitors	Comment	Organism	Structure
auranofin	5-10 nM, 50% inhibition, complete inhibition above 15 nM	Rattus norvegicus
gold acetate	500 nM, 50% inhibition	Rattus norvegicus
gold sodium thiomalate	500 nM, 50% inhibition	Rattus norvegicus
sodium aurothiosulfate	100 nM, 50% inhibition	Rattus norvegicus
triphenyl phosphine gold chloride	75 nM, 50% inhibition	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH	-	Rattus norvegicus	2-nitro-5-thiobenzoate + NADP+	-	?
thioredoxin + NADP+	-	Rattus norvegicus	thioredoxin disulfide + NADPH	-	?

Synonyms

Synonyms	Comment	Organism
thioredoxin reductase	-	Rattus norvegicus
TrxR1	-	Rattus norvegicus

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Release 2023.1 (January 2023)