Literature summary for 1.8.1.9 extracted from

Mura, P.; Camalli, M.; Bindoli, A.; Sorrentino, F.; Casini, A.; Gabbiani, C.; Corsini, M.; Zanello, P.; Rigobello, M.P.; Messori, L.
Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compound (2007), J. Med. Chem., 50, 5871-5874.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-aminothiazolium [trans-tetrachlorobis(2-aminothiazole)ruthenate(III)]	-	Rattus norvegicus
trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]	selective inhibition of TrxR1	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	O89049	-	-

Synonyms

Synonyms	Comment	Organism
thioredoxin reductase	-	Rattus norvegicus
TrxR1	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0086	-	-	Rattus norvegicus	2-aminothiazolium [trans-tetrachlorobis(2-aminothiazole)ruthenate(III)]
0.0238	-	-	Rattus norvegicus	trans-[bis(2-amino-5-methylthiazole)tetrachlororuthenate(III)]

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Release 2023.1 (January 2023)